Choosing a second generation antidepressant for treatment. In addition, indirect comparisons were made between trials by combining results of efficacy when compared with a common comparator treatment. Conventional metaanalyses have shown inconsistent results for efficacy of secondgeneration antidepressants. Comparative efficacy and acceptability of 12 newgeneration. Although there has been a lot of public debate about the role of antidepressants, a robust metaanalysis by cipriani et al 1 has demonstrated that antidepressants are more effective than placebo in the treatment of major depressive disorder. In major depressive disorder, antidepressant drugs.
Comparative efficacy and tolerability of newgeneration. Selective publication of antidepressant trials and its influence on apparent efficacy. Guide to antidepressant medications truth in drugs. Comparative efficacy and acceptability of pharmacological. Comparative efficacy and acceptability of psychotherapies for depression in children and adolescents. How they stack up researchers rank 12 common antidepressants on efficacy, acceptability. Newgeneration antidepressant drugs, including serotonin selective reuptake inhibitors and serotonin norepinephrine reuptake inhibitors, have gained wide acceptance.
Included studies were randomised controlled trials rcts that compared any of 12 newgeneration antidepressants bupropion, citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, milnaciprin, mirtazapine, paroxetine, reboxetine, sertraline, and venlafaxine as monotherapy for acutephase. Assessing and enhancing the effectiveness of antidepressants. Dropout rate was used to represent acceptability, because the authors believed it to be a more clinically meaningful measure than either side effects or symptom scores. Efficacy and acceptability of antidepressants takehome message. What is the relative efficacy of 12 newgeneration antidepressants for relieving major depression. Comparative efficacy and acceptability of amitriptyline. When starting an antidepressant, try either of these 2. Cipriani a1, furukawa ta, salanti g, geddes jr, higgins jp, churchill r, watanabe n, nakagawa a, omori im, mcguire h, tansella m, barbui c.
Comparative efficacy and acceptability of seven augmentation agents for treatmentresistant depression. Andrea cipriani department of medicine and public health, section of psychiatry and clinical psychology, university of verona, italy. Au cipriani a, furukawa ta, salanti g, geddes jr, higgins jp, churchill r, watanabe n, nakagawa a, omori im, mcguire h, tansella m, barbui c. We report an overview of all randomised controlled trials that compared 12 newgeneration antidepressants in terms of efficacy and acceptability in the. Efficacy and acceptability of group cognitive behavioral therapy for depression. Comparative efficacy and acceptability of psychotherapies. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder. Comparative effectiveness of secondgeneration antidepressants in the pharmacologic treatment of adult depression.
This is the newest nma and therefore these results are very important in terms of. Comparative efficacy and acceptability were analyzed. Citeseerx comparative efficacy and acceptability of 12. Comparative efficacy and acceptability of newgeneration. Previous pairwise metaanalyses were done to evaluate the efficacy of all types of antidepressants8.
Comparative efficacy and acceptability of firstgeneration. Comparative efficacy and acceptability of newgeneration antidepressants. Comparative efficacy and acceptability of firstgeneration and secondgeneration antidepressants in the acute treatment of major depression. Perhaps most importantly, this metaanalysis does not answer key questions about the use of antidepressants, including their effect on milder forms of depression, their effects beyond eight weeks of treatment, the harms associated with specific agents and their magnitude, and the effectiveness of antidepressants outside the confines of. Reproduced from cipriani a, furukawa ta, salanti g, et al 2009. Comparative efficacy and tolerability of newgeneration antidepressants for major depressive disorder in children and adolescents. Comparative efficacy, acceptability, and tolerability of. Comparative efficacy and tolerability of firstgeneration. Data were analyzed for comparative efficacy among antidepressants and for adverse effects.
We expressed these using fluoxetine as reference drug, because it was the first among these 12 antidepressants to be marketed in europe and the usa, and it has been consistently used as reference drug among the different pairwise comparisons. The results will also have implications for clinical practice and further research. We therefore did a multipletreatments metaanalysis, which accounts for both direct and indirect comparisons, to assess the effects of 12 newgeneration antidepressants on major depression. Comparative efficacy and acceptability of amitriptyline, duloxetine and milnacipran in fibromyalgia syndrome. We therefore did a multipletreatments metaanalysis, which accounts for both direct and indirect comparisons, to assess the effects of 12 newgeneration antidepressants. In their view, methodological shortcomings limit the validity of our results and the conclusions reached. Differences in efficacy and acceptability exist for 12 newgeneration antidepressants for major depression, year. We will use mtm to estimate the comparative efficacy and acceptability of the twelve most frequently used new generation antidepressants for acute treatment of major depression. Comparative efficacy and acceptability of pharmacological treatments for posttraumatic stress disorder in adults. We report an overview of all randomised controlled trials that compared 12 newgeneration antidepressants in terms of efficacy and acceptability in the acutephase treatment of major depression. A large metaanalysis found these medications to be superior to other newgeneration antidepressants. Pdf comparative efficacy and acceptability of 12 new. Comparative efficacy and tolerability of antidepressants.
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